The Wisconsin congressman tells KRDO-TV in Colorado Springs that he personally doesn't approve of medical marijuana laws. But he says that states should have the right to choose whether to legalize the drug for medical purposes.
In response to a reporter's question, Ryan said: "It's up to Coloradans to decide."
The interview was taped while Ryan campaigned this week in Colorado Springs and aired Friday.
Colorado is one of 17 states, plus the District of Columbia, that allow medical marijuana.
The Obama administration at first signaled that it wouldn't interfere with state-sanctioned marijuana distribution. But the Justice Department has since angered marijuana activists by shutting down dispensaries in California and Colorado.