The 41-year-old Ibanez hit a fourth-inning blast 438 feet into the right-field second deck and a 421-foot shot to center in the seventh. He has the fourth most homers in a season for a 41-year-old player, five shy of tying Ted Williams' record of 29 set in 1960 his final season.
It was Ibanez' 19th career multiple home run game third this season. He has 150 home runs with the Mariners.
Kyle Seager and Kendrys Morales added home runs as the Mariners broke the franchise record by homering in their 20th consecutive game. They did it in 19 straight from Sept. 7-27, 1999. The major league record is 27 set by Texas in 2002.
Ibanez, who also had an RBI double in the first, has 34 home runs since turning 40 on June 2, 2012. He hit only 28 home runs in 371 games before that birthday.
Joe Saunders (8-8) worked seven scoreless innings and allowed five hits. He walked two and struck out five. He is 5-3 with a 2.37 in his last nine starts. In 17 career starts at Safeco Field, he is 11-3 with a 2.62 ERA.
Jerome Williams (5-5), who lasted just 3 1-3 innings, gave up six runs and seven hits. He entered 4-1 with a 2.74 ERA in 10 career appearances against Seattle.
The Angels had back-to-back doubles in the second, but didn't score.
Mark Trumbo hit a one-out double into the right-center gap. Alberto Callaspo then lofted a ball down the right-field line that landed in front of three fielders and just inside the line. Trumbo had to hold up, and couldn't score. Saunders struck out the next two batters.
Seager opened the second with a homer to right, his 15th. That extended his hitting streak to 12 games, his third double-digit run this season.
Ibanez started the Mariners' four-run fourth with his first homer of the night.
Mike Zunino, who had a career-high three hits, and Dustin Ackley had RBI singles in the fourth. Another run scored on Garrett Richards' wild pitch.
Richards gave up Ibanez's two-out shot in the seventh. On the next pitch, Morales homered over the center-field wall, his 14th of the season. The Mariners have hit back-to-back homers this season, with five started by Ibanez.
With Saunders gone, the Angels had a three-run eighth off three relievers. Mike Trout had a RBI triple, Albert Pujols had a RBI single, and Trumbo added an RBI.
NOTES: The Mariners sent RHP Erasmo Ramirez, who started Thursday, to Class A Everett and RHP Blake Beavan to Triple-A Tacoma. LHP Bobby LaFromboise and RHP Hector Noesi were recalled. The club wants to keep Ramirez in rotation during the All-Star break. Seattle also wants Beavan to establish a starting role. It is LaFromboise's second stint with the Mariners and Noesi's third. . Los Angeles RHP Tommy Hanson (right forearm strain) will throw a simulated game Saturday. Three other pitchers, RHP Ryan Madson (right elbow), LHP Sean Burnett (left elbow impingement), and LHP Jason Vargas (blood clot) are throwing but not close to returning.