Boston rallied from an early 5-1 deficit, using two-run homers from Dustin Pedroia and Mike Napoli along with Bradley's solo shot to come back against the Mariners. Pedroia and Napoli homered in the third inning and Bradley gave Boston the lead in the fifth. Victorino's drive was part of a three-run eighth.
Seattle was just as potent early, with Kendrys Morales going deep twice, but couldn't solve the Red Sox bullpen. Alfredo Aceves, Craig Breslow and Andrew Bailey kept Seattle scoreless for 4 2-3 innings after starter Allen Webster was tagged for seven earned runs in 2 1-3 innings.
Seattle got a run off Junichi Tazawa in the eighth, but Koji Uehara pitched the ninth for his sixth save. Breslow (3-2) got the victory after throwing 2 1-3 innings.
David Ortiz had four hits including a solo home run in the second off struggling Seattle starter Hisashi Iwakuma to give him 1,688 hits as a designated hitter, tying Harold Baines for the career record. Ortiz doubled twice and singled in the eighth.
Seattle took a 5-1 lead in the second when rookie Brad Miller lined a three-run double into the right-field corner, but the lead was gone by the time the Mariners got back to the plate. Boston sent nine batters to the plate and scored five times in the third, highlighted by two-run homers from Pedroia and Napoli, sandwiched around a double from Ortiz that missed clearing the fence by only a couple of feet.
Pedroia added an RBI single in the fourth and Bradley gave the Red Sox the lead in the fifth when he hit a hanging curveball from Blake Beavan (0-2) to right-center for his second homer. Bradley was recalled from Triple-A Pawtucket earlier in the day to help provide depth in the outfield with Jacoby Ellsbury (wrist) and Victorino (hamstring) nursing nagging injuries.
Morales' two-run shot in the first was thanks to the hustle of Raul Ibanez beating out a potential double play and extending the inning. Morales added a solo homer on the first pitch of the third inning and Seattle got an RBI triple from Michael Saunders, but the Mariners left runners at the corners in the fourth inning and never threatened again until the eighth.
Iwakuma lasted just three innings, the shortest start of his career, continuing a recent stretch of rough starts for the first-time All-Star. In his first 14 starts, Iwakuma was 7-1 with a 1.79 ERA, allowing 10 home runs and 22 earned runs. In his last five starts his ERA has ballooned to 6.83. He has given up 10 homers and 22 earned runs during the winless span.
NOTES: Boston hit five homers in a game for the second time this season. The Red Sox season high is six against Toronto on April 7. ... Seattle scored in the final five innings on Monday and first three innings on Tuesday. The eight straight innings with a run set a club record. ... The Red Sox placed reliever Alex Wilson on the 15-day DL with a thumb injury. He returned to Boston for further examination.